What Are Cannabinoids?
Cannabinoids are the primary chemical compounds produced by the cannabis plant and there are more than 85 identified cannabinoids. Tetrahydrocannabinol (THC) is the most well-known cannabinoid produced by the cannabis plant and is the ONLY psychoactive cannabinoid. Of the 85+ non-psychoactive cannabinoids, Cannabidiol (CBD) is the most widely known.
What is CBD and how does it work?
CBD is an abbreviation for cannabidiol, the most prominent naturally occurring cannabinoid component found in hemp, and comprises up to 40% of the hemp plant.
According to the US Government, cannabidiol is “…devoid of psychoactive effect.” After THC (9-tetrahydrocannabinol), CBD is by far the most studied natural cannabinoid. Additionally, CBD is increasingly the subject of advanced medical research and may be the single most important cannabinoid ever discovered.
Is CBD and THC the same thing?
No, they are different compounds. CBD and THC are both cannabinoids, but THC produces psychoactive effects causing a drugged symptom commonly known as a “high”. Although all CBD extractions will contain some THC, our CBD hemp plants are selected, cultivated, and processed to eliminate all THC content and are therefore devoid of any psychoactive effects.
Is this medical cannabis and do I need a doctor’s recommendation?
Because CBD is not psychoactive, a doctor’s recommendation is not necessary, however, we do advise you to consult your physician to be sure CBD is appropriate for you.
What Are Neuroprotectants?
Neuroprotectants promote the proper function of the central nervous system (CNS). Suboptimal blood flow in your brain can decrease cognitive functions. Neuroprotectants can help maintain healthy blood flow by counteracting factors that can affect blood flow in the brain.
Antioxidants assist the human endocannabinoid system (ECS) in its pursuit of eliminating environmental threats. Research has shown that the ECS regulates homeostasis. Introducing additional sources of antioxidants to your diet may assist in maintaining homeostasis.
CBD-Oil and Water-Don’t mix with medications
If oil and water don’t mix then why would you mix your medications and CBD?
It always amazes me what some Doctors recommendations to their patients. Recently, had a phone call from a potential client they needed CBD as of today because their MD recommended it for sleep. I follow up with a phone call as they were in the store with a CBD product in hand, ready to purchase. I ask are you currently taking any medications. They say YES! Then I get why are you asking? The short answer is recent studies have shown that CBD inactivates cytochrome P450 isozymes in the short term. The long answer is that cannabinoids specifically CBD will inhibit the function of the P450 liver enzyme that clears toxins (medications) which in turn keeps them in your system longer which may lead to a toxic drug effects.
CBD is metabolized, among others, via the CYP3A4 enzyme. Various drugs such as ketoconazol (Antifungal), itraconazol (Antifungal), ritonavir (HIV antiviral), and clarithromycin (Antibiotics) inhibit this enzyme which leads to higher CBD doses that are longer pharmaceutically active. In contrast, phenobarbital (Barbiturate), rifampicin (Antibiotics), carbamazepine (Anticonvulsant), and phenytoin (Anticonvulsant) induce CYP3A4, causing reduced CBD bioavailability.
KNOW WHAT DRUGs YOUR PATIENTS ARE TAKING BEFORE RECOMMENDING CBD!
This may lead to other health problems developing. So, don’t just go and blindly pick something off the shelf at the store because your doctor said so. You may be setting yourself up for toxic overload. I recommended finding educated individuals or healthcare practitioner when trying to navigate using cannabinoids or nutritional products.
Also, note that CBD is fat soluble (lipophilic) which means you should take with meals so the liver can break it down with bile salts. Don’t ever take CBD with your prescriptions.
The reality is more complex. To learn more contact BagnellSolutions.com
-Dr. Lawrence Bagnell 10/03/2018
Lipophilic defined: tending to combine with or dissolve in lipids or fats.
Resourced from: Cannabis and Cannabinoid Research,Volume 2.1, 2017,DOI: 10.1089/can.2016.0034/An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies,Kerstin Iffland and Franjo Grotenhermen / CBD-drug interactions.